Investigating the generators of the scalp recorded visuo-verbal P300 using cortically constrained source localization.

摘要: Considerable ambiguity exists about the generators of scalp recorded P300, despite a vast body research employing diverse range methodologies. Previous investigations source localization techniques have been limited largely to equivalent current dipole models, with most studies identifying medial temporal and/or hippocampal sources, but providing little information contribution other cortical regions generation P3. Event-related potentials (ERPs) were from 5 subjects using 124-channel sensor array during performance visuo-verbal Oddball task. Cortically constrained, MRI-guided boundary element modeling was used identify this target P3 in individual subjects. Cortical localized principally intraparietal sulcus (IPS) and surrounding superior parietal lobes (SPL) bilaterally all subjects, though some variability across Two also showed activity lingual/inferior occipital gyrus mid-fusiform gyrus. A group surface calculated by non-linear warping each subject's segmented cortex followed averaging creation mesh. Source identified reflected subject activations IPS SPL primarily on left. Activation is interpreted reflect role region working memory related attention processes visuo-motor integration. The left taken activation associated modality-specific analysis visual word forms.