Improved exercise ejection fraction with long-term prazosin therapy in patients with heart failure
作者： Stephen A. Goldman , Lynne L. Johnson , Edith Escala , Paul J. Cannon , Melvin B. Weiss
DOI: 10.1016/0002-9343(80)90158-8
关键词:
摘要: Abstract To study the effect of prazosin therapy on left ventricular function in patients with chronic stable heart failure, first pass radionuclide angiography at rest and during exercise was performed 15 before administration after seven to 12 weeks therapy. There no significant change resting ejection fraction (36 ± 14 per cent versus 37 cent) (mean standard deviation). However, increased from 34 42 17 (p These data suggest that long-term is effective treatment failure. beneficial effects prazosin, an alpha 1 blocking agent, may be evident only exercise.
amjmed.com
elsevier.com
sci-hub.se 参考文章(26)
Arthur C. Guyton, Determination of Cardiac Output By Equating Venous Return Curves With Cardiac Response Curves Physiological Reviews. ,vol. 35, pp. 123- 129 ,(1955) , 10.1152/PHYSREV.1955.35.1.123
G S Stokes, L M Stoker, R M Graham, H F Oates, Alpha blocking action of the antihypertensive agent, prazosin. Journal of Pharmacology and Experimental Therapeutics. ,vol. 201, pp. 747- 752 ,(1977)
RICHARD S. KRAMER, DEAN T. MASON, EUGENE BRAUNWALD, Augmented Sympathetic Neurotransmitter Activity in the Peripheral Vascular Bed of Patients with Congestive Heart Failure and Cardiac Norepinephrine Depletion Circulation. ,vol. 38, pp. 629- 634 ,(1968) , 10.1161/01.CIR.38.4.629
H. Ibsen, K. Rasmussen, H. ærenlund Jensen, A. Leth, Changes in plasma volume and extracellular fluid volume after addition of prazosin to propranolol treatment in patients with hypertension. Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 38, pp. 425- 429 ,(1978) , 10.1080/00365517809108446
N A Awan, R R Miller, D T Mason, Comparison of effects of nitroprusside and prazosin on left ventricular function and the peripheral circulation in chronic refractory congestive heart failure. Circulation. ,vol. 57, pp. 152- 159 ,(1978) , 10.1161/01.CIR.57.1.152
J.C. DOXEY, C.F.C. SMITH, JULIE M. WALKER, SELECTIVITY OF BLOCKING AGENTS FOR PRE- AND POSTSYNAPTIC α-ADRENOCEPTORS British Journal of Pharmacology. ,vol. 60, pp. 91- 96 ,(1977) , 10.1111/J.1476-5381.1977.TB16752.X
P Ludbrook, J S Karliner, K Peterson, G Leopold, R A O'Rourke, Comparison of ultrasound and cineangiographic measurements of left ventricular performance in patients with and without wall motion abnormalities. Heart. ,vol. 35, pp. 1026- 1032 ,(1973) , 10.1136/HRT.35.10.1026
Robert Zelis, Dean T. Mason, Compensatory Mechanisms in Congestive Heart Failure — The Role of the Peripheral Resistance Vessels New England Journal of Medicine. ,vol. 282, pp. 962- 964 ,(1970) , 10.1056/NEJM197004232821707
R R Miller, L A Vismara, D O Williams, E A Amsterdam, D T Mason, Pharmacological mechanisms for left ventricular unloading in clinical congestive heart failure. Differential effects of nitroprusside, phentolamine, and nitroglycerin on cardiac function and peripheral circulation. Circulation Research. ,vol. 39, pp. 127- 133 ,(1976) , 10.1161/01.RES.39.1.127
Charles B. Higgins, Stephen F. Vatner, Dean Franklin, Eugene Braunwald, Effects of Experimentally Produced Heart Failure on the Peripheral Vascular Response to Severe Exercise in Conscious Dogs Circulation Research. ,vol. 31, pp. 186- 194 ,(1972) , 10.1161/01.RES.31.2.186