Cells of Origin for Prostate Cancer

摘要: Comprehensive knowledge of the normal prostate epithelial lineage hierarchy is a prerequisite to investigate identity cells origin for cancer. The basal and luminal constitute most epithelium have been major focuses study on Much progress has made during past few decades, mainly using mouse models, understand inter-lineage relationship intra-lineage heterogeneity in adults as well plasticity conditions stress. These studies concluded that adult are largely independently sustained under physiological conditions, but both types possess capacity bipotent differentiation stress or artificial experimental conditions. However, existence putative progenitors within each warrants further investigation. Whether human completely same remains uncertain. Experiments from independent groups demonstrated mice humans can serve targets transformation. But controversies remain whether disease distinct display different clinical behaviors. Further investigation will provide new insights into this issue. Understanding cancer help identify novel prognostic markers early detection aggressive cancers, therapeutic vulnerability these tumors, inspire strategies.