Bcl-2 and Bcl-2-Related Proteins in Apoptosis Regulation
作者： L. H. Boise , A. R. Gottschalk , J. Quintáns , C. B. Thompson
DOI: 10.1007/978-3-642-79437-7_8
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摘要: Apoptosis is a form of cell death critical for the normal development multicellular organisms (Kerr et al. 1972; Wyllie 1980). It characterized by morphological and biochemical criteria consisting of: nuclear shrinkage, chromatin condensation, cytoplasmic blebbing, internucleosomal DNA fragmentation 1980; Cohen Duke 1992). As opposed to other forms death, apoptosis does not induce an inflammatory response. There are number ways which can be induced, including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation, glucocorticoids (Cohen Within immune system, regulation appears crucial prevention autoimmune disease. Immature lymphocytes particularly susceptible apoptosis, as 95% thymocytes die in situ during development. Self-reactive eliminated from repertoire following engagement their antigen-specific receptors. Thus, process clonal deletion allows elimination self-reactive without initiating
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