Inhibition of Borna disease virus replication by ribavirin.
作者： Ingo Jordan , Thomas Briese , Devron R. Averett , W. Ian Lipkin
DOI: 10.1128/JVI.73.9.7903-7906.1999
关键词:
摘要: The guanosine analogue ribavirin was tested for antiviral activity in two neural cell lines, human oligodendrocytes and rat glia, against Borna disease virus (BDV) strains V He/80. Ribavirin treatment resulted lower levels of viral transcripts within 12 h. Addition but not adenosine a profound reduction the effect. appears to be an effective agent BDV infection vitro. A likely mechanism its is intracellular GTP pool, resulting inhibition transcription capping mRNAs.
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