Lymphoid development from hematopoietic stem cells.

摘要: Mechanisms and pathways for commitment to the lymphoid lineage from hematopoietic stem cells (HSC) remain controversial. The interleukin-7 receptor (IL-7R) transduces nonredundant signals both T- B-cell development. Recently, we identified a clonogenic common progenitor population in mouse bone marrow that can give rise T, B, natural killer (NK) cells, but lacks myeloid differentiation capacity. These are not self-renewing progenitors have limited life span. HSC do express IL-7R, upregulation of IL-7R occurs at stage progenitors. mediates reinforce survival developing T promote rearrangement immunoglobulin heavy chain genes Thus, exist early hematopoiesis, expression is critical step initiation development HSC.