Hematological Complications in Obstetrics, Pregnancy, and Gynecology: Hereditary and acquired thrombophilia in pregnancy

摘要: Introduction Thrombophilia in pregnancy represents a challenging problem for obstetricians, reproductive medicine specialists and hematologists. Normal is known to be associated with an enhanced risk of deep vein thrombosis (DVT) pulmonary embolus (PE). When combined thrombophilic disorder, this significantly enhanced, usually considered about 5–8-fold elevated normal pregnant women, addition thrombophilia, or other clinically significant factor, requires particular attention avoid unnecessary fetal loss maternal morbidity mortality. obstetrics not only risks DVT PE, but also recurrent miscarriage syndrome, infertility, stillborn births, eclampsia intrauterine growth retardation, pre-eclampsia, frank eclampsia, HELLP syndrome abruption, the additional usual thrombohemorrhagic complications, such as disseminated intravascular coagulation. Indeed many women undiagnosed thrombophilia will experience their first clinical manifestation when – without PE. In addition, patients who have had prior DVT/PE harbor thus emphasizing importance adequate investigation suggestive personal family history warrants. This chapter summarizes (1) antithrombotic approaches factors, (2) thrombophilias concern obstetrician, specialist hematologist. treatment discussions recommendations discussed general then, necessary, any disorder. It must appreciated course patients, particularly during pregnancy, highly dynamic.