Transplantation of peripheral blood progenitor cells from HLA-identical sibling donors

摘要: Transplantation of peripheral blood progenitor cells (PBPCs) has largely replaced autologous bone marrow transplantation. The same might occur in the allogeneic setting if favourable initial experience with PBPCT is confirmed. We analysed all primary transplants utilizing unmodified PBPC from HLA-identical sibling donors reported to European Group for Blood and Marrow (EBMT) 1994. 59 patients a median age 39 years received myeloablative therapy acute myelogenous leukaemia (23 patients, lymphoblastic (13), chronic (nine), lymphoma (seven), or other diagnoses (seven) mostly advanced stages followed by transplantation PBPC. Three died soon after grafting, others showed prompt haemopoietic recovery times recover an absolute neutrophil count (ANC) above 0.5 1.0 x 10(9)/I 15 (range 9-27) 17d 10-28) respectively. Time platelet 20 50 was 16 9-76) 18d 12-100) 27 (46%) developed no mild graft-versus-host disease (GVIID). incidence moderate (grade II) 27%; 24% severe GVHD (grades III IV), 55% who were alive 90d GVHD, probability develop extensive 32% (95% confidence interval 22-42) follow-up 14 months. Overall event-free survival (EFS) at 1 year 54% (CI 48-60) 50% 43-57), respectively, relapse 23% 17-29). EFS 67% 55-79) transplanted leukaemias first complete remission, phase, aplastic anaemia. resulted durable engraftment. severity seemed comparable that observed BMT. this cohort most whom suffered lymphoma, encouraging, suggesting high numbers T lymphocytes and/or natural killer contained typical collection product exert vigorous graft-versus-leukaemia effect. Further evaluation highly desirable.