摘要: Cerebral ischemia induces excess release of glutamate and an increase in the intracellular Ca2+ concentration, which provoke catastrophic enzymatic processes leading to irreversible neuronal injury. Histamine plays role neurotransmitter central nervous system, histaminergic fibers are widely distributed brain. In cerebral ischemia, histamine from nerve endings has been shown be enhanced by facilitation its activity. An inhibition activity aggravates histologic outcome. contrast, intracerebroventricular administration improves aggravation, whereas blockade H2 receptors ischemic Furthermore, enhances dopamine. These findings suggest that provides beneficial effects against damage suppressing excitatory neurotransmitters. However, action facilitates permeability blood-brain barrier shows deleterious on edema.
sci-hub.se 参考文章(41)
James E. McGuigan, A consideration of the adverse effects of cimetidine Gastroenterology. ,vol. 80, pp. 181- 192 ,(1981) , 10.1016/0016-5085(81)90212-2
Takehiko Watanabe, Yoshitaka Taguchi, Sadao Shiosaka, Junya Tanaka, Hiroaki Kubota, Yoshitake Terano, Masaya Tohyama, Hiroshi Wada, Distribution of the histaminergic neuron system in the central nervous system of rats; a fluorescent immunohistochemical analysis with histidine decar☐ylase as a marker Brain Research. ,vol. 295, pp. 13- 25 ,(1984) , 10.1016/0006-8993(84)90811-4
James A. Clemens, Lee A. Phebus, Dopamine depletion protects striatal neurons from ischemia-induced cell death Life Sciences. ,vol. 42, pp. 707- 713 ,(1988) , 10.1016/0024-3205(88)90463-8
Hiroshi Wada, Naoyuki Inagaki, Nobuko Itowi, Atsushi Yamatodani, Histaminergic neuron system in the brain: distribution and possible functions. Brain Research Bulletin. ,vol. 27, pp. 367- 370 ,(1991) , 10.1016/0361-9230(91)90126-5
Naoto Adachi, Frank J. Seyfried, Tatsuru Arai, Blockade of central histaminergic H2 receptors aggravates ischemic neuronal damage in gerbil hippocampus. Critical Care Medicine. ,vol. 29, pp. 1189- 1194 ,(2001) , 10.1097/00003246-200106000-00021
Mordecai Y.-T. Globus, Myron D. Ginsberg, W.Dalton Dietrich, Raul Busto, Peritz Scheinberg, Substantia nigra lesion protects against ischemic damage in the striatum. Neuroscience Letters. ,vol. 80, pp. 251- 256 ,(1987) , 10.1016/0304-3940(87)90463-0
Koreaki Sugimoto, Koji Abe, Tsong-Hai Lee, Eiko Sakurai, Kazuhiko Yanai, Kyuya Kogure, Yasuto Itoyama, Takehiko Watanabe, Histamine depletion in brain caused by treatment with (S) α-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons Brain Research. ,vol. 666, pp. 279- 283 ,(1994) , 10.1016/0006-8993(94)90784-6
P. Panula, H. Y. Yang, E. Costa, Histamine-containing neurons in the rat hypothalamus. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 81, pp. 2572- 2576 ,(1984) , 10.1073/PNAS.81.8.2572
Masafumi Shimokawa, Koujirou Yamamoto, Junichi Kawakami, Yasufumi Sawada, Tatsuji Iga, Neurotoxic convulsions induced by histamine H2 receptor antagonists in mice Toxicology and Applied Pharmacology. ,vol. 136, pp. 317- 323 ,(1996) , 10.1006/TAAP.1996.0038
Akira Mitani, Yasushi Andou, Seizo Masuda, Kiyoshi Kataoka, Transient forebrain ischemia of three-minute duration consistently induces severe neuronal damage in field CA1 of the hippocampus in the normothermic gerbil Neuroscience Letters. ,vol. 131, pp. 171- 174 ,(1991) , 10.1016/0304-3940(91)90606-T