Association between cardiovascular events and sodium-containing effervescent, dispersible, and soluble drugs: nested case-control study

摘要: Objective To determine whether patients taking formulations of drugs that contain sodium have a higher incidence cardiovascular events compared with on non-sodium the same drugs. Design Nested case-control study. Setting UK Primary Care Patients registered Clinical Practice Research Datalink (CPRD). Participants All aged 18 or over who were prescribed at least two prescriptions sodium-containing matched standard drug between January 1987 and December 2010. Main outcome measures Composite primary incident non-fatal myocardial infarction, stroke, vascular death. We performed 1:1 density sampling controls using For secondary analyses, cases individual components study composite endpoint hypertension, heart failure, all cause mortality. Results 1 292 337 included in cohort. Mean follow-up time was 7.23 years. A total 61 072 an event controls. death adjusted odds ratio for exposure to 1.16 (95% confidence interval 1.12 1.21). The ratios endpoints 1.22 (1.16 1.29) 1.28 (1.23 1.33) mortality, 7.18 (6.74 7.65) 0.98 (0.93 1.04) 0.94 (0.88 1.00) 0.70 (0.31 1.59) median from date first prescription (that is, entry into cohort) 3.92 Conclusions Exposure effervescent, dispersible, soluble medicines associated significantly increased adverse those Sodium-containing should be caution only if perceived benefits outweigh these risks.