Targeting the dopamine D3 receptor: an overview of drug design strategies

作者: Antoni Cortés , Estefanía Moreno , Mar Rodríguez-Ruiz , Enric I. Canela , Vicent Casadó

DOI: 10.1080/17460441.2016.1185413

关键词:

摘要: Introduction: Dopamine is a neurotransmitter widely distributed in both the periphery and central nervous system (CNS). Its physiological effects are mediated by five closely related G protein-...

参考文章(258)
Jeffrey A Lieberman, Dopamine partial agonists: a new class of antipsychotic. CNS Drugs. ,vol. 18, pp. 251- 267 ,(2004) , 10.2165/00023210-200418040-00005
Bernard Le Foll, Ginetta Collo, Eugenii A. Rabiner, Isabelle Boileau, Emilio Merlo Pich, Pierre Sokoloff, Dopamine D3 receptor ligands for drug addiction treatment: update on recent findings. Progress in Brain Research. ,vol. 211, pp. 255- 275 ,(2014) , 10.1016/B978-0-444-63425-2.00011-8
Sergi Ferré, Jordi Bonaventura, Dardo Tomasi, Gemma Navarro, Estefanía Moreno, Antonio Cortés, Carme Lluís, Vicent Casadó, Nora D. Volkow, Allosteric mechanisms within the adenosine A2A–dopamine D2 receptor heterotetramer Neuropharmacology. ,vol. 104, pp. 154- 160 ,(2016) , 10.1016/J.NEUROPHARM.2015.05.028
Gerhard Gross, Karla Drescher, The role of dopamine D(3) receptors in antipsychotic activity and cognitive functions. Handbook of experimental pharmacology. pp. 167- 210 ,(2012) , 10.1007/978-3-642-25758-2_7
Rui Song, Ri-Fang Yang, Ning Wu, Rui-Bin Su, Jin Li, Xiao-Qing Peng, Xia Li, József Gaál, Zheng-Xiong Xi, Eliot L. Gardner, YQA14: a novel dopamine D3 receptor antagonist that inhibits cocaine self-administration in rats and mice, but not in D3 receptor-knockout mice. Addiction Biology. ,vol. 17, pp. 259- 273 ,(2012) , 10.1111/J.1369-1600.2011.00317.X
Christian A. Heidbreder, Amy H. Newman, Current perspectives on selective dopamine D(3) receptor antagonists as pharmacotherapeutics for addictions and related disorders. Annals of the New York Academy of Sciences. ,vol. 1187, pp. 4- 34 ,(2010) , 10.1111/J.1749-6632.2009.05149.X
Ginetta Collo, Federica Bono, Laura Cavalleri, Laura Plebani, Emilio Merlo Pich, Mark J. Millan, Pier Franco Spano, Cristina Missale, Pre-synaptic dopamine D3 receptor mediates cocaine-induced structural plasticity in mesencephalic dopaminergic neurons via ERK and Akt pathways Journal of Neurochemistry. ,vol. 120, pp. 765- 778 ,(2012) , 10.1111/J.1471-4159.2011.07618.X
Laurence J Miller, Maoqing Dong, Kaleeckal G Harikumar, Ligand binding and activation of the secretin receptor, a prototypic family B G protein-coupled receptor. British Journal of Pharmacology. ,vol. 166, pp. 18- 26 ,(2012) , 10.1111/J.1476-5381.2011.01463.X
Roberto Maggio, Marco Scarselli, Francesca Novi, Mark J. Millan, Giovanni U. Corsini, Potent activation of dopamine D3/D2 heterodimers by the antiparkinsonian agents, S32504, pramipexole and ropinirole. Journal of Neurochemistry. ,vol. 87, pp. 631- 641 ,(2003) , 10.1046/J.1471-4159.2003.02038.X