Cognitive Effects of Lithium Carbonate and Haloperidol in Treatment-Resistant Aggressive Children

摘要: • The effects of lithium carbonate and haloperidol on cognition were examined in a placebo-controlled, double-blind study 61 treatment-resistant, hospitalized school-aged children. They all had DSM-III diagnosis conduct disorder— undersocialized, aggressive, with profile highly explosive aggressive behavior. Children assessed at the end two-week placebo-baseline period again after four weeks treatment. Drug mild. Haloperidol (mean dose, 2.95 mg/day) caused significant decreases Porteus Maze test quotient scores slowing reaction time (RT) simple RT task. Lithium 1,166 adversely affected qualitative test. No treatment found for Matching Familiar Figures Test, short-term recognition memory concept attainment tasks, or Stroop Test.