Complications and adverse outcomes in pregnancy and childbirth among women who conceived by assisted reproductive technologies: a nationwide birth cohort study of Japan environment and children’s study

摘要: Although pregnancies conceived by assisted reproductive technology (ART) have a higher risk of maternal/perinatal complications, the overall adverse outcomes necessitating advanced obstetric care has not been closely examined. The present study aimed to assess and compare complications in pregnancy childbirth ART with those naturally. This was conducted as part Japan environment children’s (JECS), an ongoing nationwide birth cohort Japan. assessed mode conception (natural conception, ovulation induction [OI] without ART, conventional vitro fertilization embryo transfer [IVF-ET], or intracytoplasmic sperm injection [ICSI]) using logistic regression generalized estimating equations controlling for potential confounders. final dataset included women who naturally (N = 90,506), OI (N = 3939), IVF-ET (N = 1476), ICSI (N = 1671). Compared naturally, were at placenta previa (adjusted OR 2.90 [95% CI 1.94, 4.34]), morbidly adherent (6.85 [3.88, 12.13]), pregnancy-induced hypertension (1.40 [1.10, 1.78]) whereas had placental abruption (2.16 [1.20, 3.88]) well (2.01 [1.29, 3.13]) (7.81 [4.56, 13.38]). Women blood transfusion (conventional IVF-ET: 3.85 [2.52, 5.88]; ICSI: 3.76 [2.49, 5.66]) ICU admission 2.58 [1.11, 6.01]; 3.45 [1.68, 7.06]) even after Neonates preterm 1.42 [1.13, 1.78]; 1.31 [1.05, 1.64]). care. Obstetricians should be aware increased among this population.