Endemic Genotypes of Candida albicans Causing Fungemia Are Frequent in the Hospital

作者: Pilar Escribano , Marta Rodríguez-Créixems , Carlos Sánchez-Carrillo , Patricia Muñoz , Emilio Bouza

DOI: 10.1128/JCM.00516-13

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摘要: Genotyping of Candida albicans strains causing candidemia can uncover the presence endemic genotypes in hospital. Using a highly reproducible and discriminatory microsatellite marker panel, we studied genetic diversity 217 C. isolates from blood cultures 202 patients with (from January 2007 to December 2011). Each isolate represented 1 episode. Multiple episodes were defined as isolation further taken ≥7 days after last culture. Of patients, 188 had episode, 13 2 episodes, 3 episodes. Identical showed same alleles for all 6 markers. The both identical most (11/13; 84.6%). In contrast, different found patient one first second other third episode (isolated months later). We marked 174 genotypes: 155 unique, 19 formed clusters (2 per cluster). Up 25% infected by that or more patients. Some these unit hospital, mainly neonatology, whereas others wards.

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