Cell cycle control in mammalian cells : role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs)

摘要: All eukaryotic cells possess similar mechanisms to regulate the progression of cell cycle. However, higher eukaryotes have evolved respond a large array positive and negative signals with an intracellular or extracellular origin. These are eventually integrated by conserved protein engine consisting holoenzymes kinase activity, which trigger crucial transitions during In this review, mammalian cycle integrates different nature discussed.