Food vacuole proteome of the malarial parasite Plasmodium falciparum
作者： Mauld Lamarque , Christophe Tastet , Joël Poncet , Edith Demettre , Patrick Jouin
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摘要: The Plasmodium falciparum food vacuole (FV) is a lysosome-like organelle where erythrocyte hemoglobin digestion occurs. It favorite target in the development of antimalarials. We have used tandem mass spectrometry approach to investigate proteome an FV-enriched fraction and identified 116 proteins. electron microscopy analysis Western blot data showed that major component was FV and, as expected, majority previously known markers were recovered. Of particular interest, several proteins involved vesicle-mediated trafficking identified, which are likely play key role biogenesis and/or protein trafficking. Recovery parasite surface lends support cytostomal pathway ingestion route. 32 described hypothetical databases. This insight into content provides new clues towards understanding biological function this P. falciparum.
sci-hub.se 参考文章(78)
John Armstrong, Alison Pidoux, Sally Bowden, Mark Craighead, Neil Bone, Everton Robinson, None, The ypt proteins of Schizosaccharomyces pombe. Biochemical Society Transactions. ,vol. 22, pp. 460- 463 ,(1994) , 10.1042/BST0220460
D. Simmons, G. Woollett, M. Bergin-Cartwright, D. Kay, J. Scaife, A malaria protein exported into a new compartment within the host erythrocyte. The EMBO Journal. ,vol. 6, pp. 485- 491 ,(1987) , 10.1002/J.1460-2075.1987.TB04779.X
S.E. Francis, I.Y. Gluzman, A. Oksman, A. Knickerbocker, R. Mueller, M.L. Bryant, D.R. Sherman, D.G. Russell, D.E. Goldberg, Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase. The EMBO Journal. ,vol. 13, pp. 306- 317 ,(1994) , 10.1002/J.1460-2075.1994.TB06263.X
Nadia La Greca, Alan R Hibbs, Chris Riffkin, Michael Foley, Leann Tilley, Identification of an endoplasmic reticulum-resident calcium-binding protein with multiple EF-hand motifs in asexual stages of Plasmodium falciparum. Molecular and Biochemical Parasitology. ,vol. 89, pp. 283- 293 ,(1997) , 10.1016/S0166-6851(97)00134-5
Martin Götte, Thomas Lazar, Jin-San Yoo, Dietrich Scheglmann, Dieter Gallwitz, The full complement of yeast Ypt/Rab-GTPases and their involvement in exo- and endocytic trafficking. Sub-cellular biochemistry. ,vol. 34, pp. 133- 173 ,(2000) , 10.1007/0-306-46824-7_4
D. J. Sullivan, I. Y. Gluzman, D. G. Russell, D. E. Goldberg, On the molecular mechanism of chloroquine's antimalarial action. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 11865- 11870 ,(1996) , 10.1073/PNAS.93.21.11865
W Trager, J. Jensen, Human malaria parasites in continuous culture Science. ,vol. 193, pp. 673- 675 ,(1976) , 10.1126/SCIENCE.781840
Donald L. Gardiner, Tobias Spielmann, Matthew W. A. Dixon, Paula L. Hawthorne, Maria R. Ortega, Karen L. Anderson, Tina S. Skinner-Adams, David J. Kemp, Katharine R. Trenholme, CLAG 9 is located in the rhoptries of Plasmodium falciparum. Parasitology Research. ,vol. 93, pp. 64- 67 ,(2004) , 10.1007/S00436-004-1098-4
Mark E Wickham, Melanie Rug, Stuart A Ralph, Nectarios Klonis, Geoffrey I McFadden, Leann Tilley, Alan F Cowman, Trafficking and assembly of the cytoadherence complex in Plasmodium falciparum-infected human erythrocytes The EMBO Journal. ,vol. 20, pp. 5636- 5649 ,(2001) , 10.1093/EMBOJ/20.20.5636
Martin Hansen, Jürgen F. J. Kun, Joachim E. Schultz, Eric Beitz, A Single, Bi-functional Aquaglyceroporin in Blood-stagePlasmodium falciparum Malaria Parasites Journal of Biological Chemistry. ,vol. 277, pp. 4874- 4882 ,(2002) , 10.1074/JBC.M110683200