Differential ubiquitin-proteasome and autophagy signaling following rotator cuff tears and suprascapular nerve injury.

摘要: Previous studies have evaluated role of Akt/mTOR signaling in rotator cuff muscle atrophy and determined that there was differential following tendon transection (TT) suprascapular nerve (SSN) denervation (DN), suggesting TT DN modulated by different protein degradation pathways. In this study, two proteolytic systems been shown to be potent regulators other injury models, the ubiquitin-proteasome pathway autophagy, were DN. addition examining degradation, study assessed synthesis rate these surgical models understand how balance between results injury. contrast traditional theory is decreased during atrophy, suggests up-regulated both models. While a major contributor seen DN, autophagy TT. The findings suggest primary factor contributing However, pathways are activated if SSN involved.