Neighborhood Socioeconomic Status and Cognitive Function in Late Life

摘要: Neighborhood socioeconomic status (NSES) is associated with cognitive function, independently of individual demographic, health, and characteristics. However, research has been largely cross-sectional, mechanisms the association are unknown. In 1992-1993, Cardiovascular Health Study participants (n = 3,595; mean age 74.8 years; 15.7% black) underwent testing magnetic resonance imaging white matter hyperintensities (WMH), their addresses were geocoded. NSES was calculated using 1990 US Census data (block groups; 6 measures wealth, education, occupation). The Modified Mini-Mental State Examination (3MS) used to assess general cognition, Digit Symbol Substitution Test (DSST) speed processing annually for years. Associations race-specific tertiles 3MS, DSST, WMH estimated linear mixed-effects models accounting geographic clustering, stratified by race, adjusted (education, income, lifetime occupational status) variables. fully models, higher 3MS scores in blacks (mean difference between highest lowest 2.4 points; P 0.004) whites 0.7 0.02) at baseline but not changes over time. marginally DSST WMH. Adjustment did attenuate NSES-3MS associations. cognition late adulthood differ explained WMH, evident only baseline.