Polidocanol Plus Glucose Versus Glucose Alone for the Treatment of Telangiectasias: Triple Blind, Randomised Controlled Trial (PG3T).

摘要: Objective The aim of this study was to compare the effectiveness and safety two sclerosing agents used treat telangiectasias in lower limbs: 0.2% polidocanol + 70% hypertonic glucose (HG) vs. 75% HG alone. Methods A prospective, randomised, triple blind, controlled, parallel group trial with patients randomly assigned a 1:1 ratio between January December 2015, month follow up, from single academic medical centre Brazil, carried out. Participants were women aged 18–65 years on lateral aspect one thigh, classified as C1EpAsPn who underwent sclerotherapy session or alone an area limited by rectangular template. primary endpoint elimination within 60 days pre-treatment pattern. length vessels measured images obtained before after treatment using ImageJ software. Safety outcomes analysed immediately, 7 days, treatment, included pigmentation. Results total 115 included, 98 whom completed study. Sclerotherapy significantly more effective than target (82.2% 63.9%; p  Conclusion Polidocanol plus had better results telangiectasias. No severe adverse events occurred. Pigmentation occurred both groups shorter treated HG.