The Multiple Facets of ATRX Protein

摘要: ATRX gene codifies for a protein member of the SWI-SNF family and was cloned first time over 25 years ago as responsible rare developmental disorder characterized by α-thalassemia intellectual disability called syndrome (Alpha Thalassemia/mental Retardation X-linked). Since its discovery helicase involved in alpha-globin transcriptional regulation, our understanding multiple roles played increased continuously, leading to recognition this multifaceted central “caretaker” human genome cancer suppression. In review, we report recent advances comprehension manifold functions that encompasses heterochromatin epigenetic regulation maintenance, telomere function, replicative stress response, stability, suppression endogenous transposable elements exogenous viral genomes.