Biology of Human Alkaline Phosphatases with Special Reference to Cancer
作者： José Luis Millán , William H. Fishman , R. Stinson
DOI: 10.3109/10408369509084680
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摘要: The current information on the cloning and sequencing of four alkaline phosphatase genes (PLAP, GCAP, LAP, TNAP) has been reviewed. It has provided insights into their evolutionary history and the mechanisms of catalysis and of uncompetitive inhibition. The oncodevelopmental biology of the germ cell and its excessive GCAP eutopic expression in neoplasia are noted, and there is reason to suggest that the enzyme may serve to guide migratory cells and to transport specific molecules such as fat and immunoglobulins across …
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