Neonatal atria and ventricles secrete atrial natriuretic factor via tissue-specific secretory pathways
作者： Kenneth D. Bloch , J.G. Seidman , Janice D. Naftilan , John T. Fallon , Christine E. Seidman
DOI: 10.1016/0092-8674(86)90512-X
关键词:
摘要: The cellular mechanisms regulating secretion of the peptide hormone atrial natriuretic factor (ANF) differ in neonatal and ventricular cardiocytes. We demonstrate that although both cell types synthesize secrete ANF, only cells store abundant secretory granules. Neonatal ANF rapidly after synthesis lack propose is released by a constitutive pathway whereas stored regulated pathway. Furthermore, mRNA concentrations decrease during first week life. Developmental variation use pathways may reflect changing requirements for maintenance intravascular volume pressure. Tissue-specific modulation appears to be novel response developmentally induced changes hormone.
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