Passive Deformation Analysis of Human Leukocytes

摘要: The following analysis presents an experimental and theoretical study of the passive viscoelastic behavior human leukocytes. Individual neutrophils in EDTA were observed both during their partial aspiration into a small micropipette after expulsion from large where cell had been totally aspirated deformed sausage shape. To analyze data, model leukocyte rheology has developed consisting cortical shell containing Maxwell fluid which describes average properties cytoplasm. represents crosslinked actin layer near surface is assumed to be under pre-stressed tension. This can reproduce results experiments using for short-time deformation slow recovery data deformation. In addition, finite element scheme established same shows close agreement with analytical solution.