Methods for the synthesis of substituted purines
作者： Nathanael S. Gray , Qiang Ding , Peter G. Schultz , Sheng Ding
DOI:
关键词:
摘要: The invention provides general methods for preparing 2,9-, 2,6,9-, O6-aryl- and O6-alkyl-substituted purines in a combinatorial traceless fashion. involve, some embodiments, Mitsunobu alkylation of 2-fluoro-6-phenylsulfenylpurine at N9 with alcohols solution, followed by C2-capture the purine core resin-bound amine subsequent oxidation displacement C6 sulfonyl group amines anilines.
lens.org 参考文章(7)
Nathanael S. Gray, Qiang Ding, Sheng Ding, Kinase inhibitor scaffolds and methods for their preparation ,(2002)
Laurent Meijer, Nathanael S. Gray, Peter Schultz, Sung-Hou Kim, Purine inhibitors of protein kinases, G proteins and polymerases ,(1998)
Sheng Ding, Nathanael S. Gray, Qiang Ding, Xu Wu, Peter G. Schultz, Resin-capture and release strategy toward combinatorial libraries of 2,6,9-substituted purines. ACS Combinatorial Science. ,vol. 4, pp. 183- 186 ,(2002) , 10.1021/CC010080I
Virginie Brun, Michel Legraverend, David S Grierson, Cyclin-dependent kinase (CDK) inhibitors: development of a general strategy for the construction of 2,6,9-trisubstituted purine libraries. Part 1 Tetrahedron Letters. ,vol. 42, pp. 8161- 8164 ,(2001) , 10.1016/S0040-4039(01)01751-8
Shozo Kusachi, Robert D. Thompson, William J. Bugni, Nobuyuki Yamada, Ray A. Olsson, Dog coronary artery adenosine receptor: structure of the N6-alkyl subregion. Journal of Medicinal Chemistry. ,vol. 29, pp. 989- 996 ,(1985) , 10.1021/JM00149A016
Young-Tae Chang, Nathanael S Gray, Gustavo R Rosania, Daniel P Sutherlin, Soojin Kwon, Thea C Norman, Radhika Sarohia, Maryse Leost, Laurent Meijer, Peter G Schultz, Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. Chemistry & Biology. ,vol. 6, pp. 361- 375 ,(1999) , 10.1016/S1074-5521(99)80048-9
Sheng Ding, Nathanael S. Gray, Qiang Ding, Peter G. Schultz, A Concise and Traceless Linker Strategy toward Combinatorial Libraries of 2,6,9-Substituted Purines Journal of Organic Chemistry. ,vol. 66, pp. 8273- 8276 ,(2001) , 10.1021/JO016010F