Linkage of 11 beta-hydroxylase mutations with altered steroid biosynthesis and blood pressure in the Dahl rat.
作者： George T. Cicila , John P. Rapp , Jia-Ming Wang , Elizabeth St. Lezin , Shi Chung Ng
DOI: 10.1038/NG0493-346
关键词:
摘要: In Dahl salt-hypertension sensitive (S) and resistant (R) strains fed a high NaCl diet, 11 beta-hydroxylase polymorphisms cosegregate with the adrenal capacity to synthesize 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) blood pressure. The R rat carries an allele that: (i) differs from those of 12 other strains; (ii) is associated uniquely reduced 18-OH-DOC; (iii) encodes 5 amino acid substitutions in protein. robust salt-resistance may be due part synthesis mineralocorticoid 18-OH-DOC stemming mutations gene. beta-hydroxylase, located on chromosome 7, first candidate gene identified animal model which coding sequence have been linked regulation
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