A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial.

摘要: BACKGROUND The movement profile of older adults with compromised function is unknown, as the relationship between these profiles and development major mobility disability (MMD)-a critical clinical outcome. We first describe dimensions in then examine whether predict onset MMD. METHODS Older at risk for MMD (N = 1,022, mean age 78.7 years) were randomized to receive a structured physical activity intervention or health education control. assessed 6-month intervals (average follow-up 2.2 years until incident MMD), baseline, 6-, 12- 24-month via accelerometry. RESULTS A principal components analysis 11 accelerometer-derived metrics yielded three representing lifestyle (LM), extended bouts moderate-to-vigorous (MVPA), stationary body posture. LM accounted greatest proportion variance (53%). Within education, both baseline (HR 0.74; 95% CI 0.62 0.88) 0.69; 0.54 0.87) associated MMD, whereas only was within 0.61 0.89). There similar nonlinear relationships present (p < .04), whereby lower among individuals higher levels LM. CONCLUSIONS Both should be central treatment regimens TRIAL REGISTRATION clinicaltrials.gov Identifier NCT01072500.