Dissociation of effector functions in populations of activated macrophages

摘要: THERE is much evidence to indicate an important role for activated macrophages in resistance malignant tumours and infections caused by intracellular pathogens. Different investigators have found that may be distinguished from normal either morphological, biochemical, or functional criteria, depending on the experimental design1. Functional criteria frequently cited are killing of organisms2,3, inhibition and/or tumour cells4–6 proliferating lymphocytes7,8. Previous work our laboratory has demonstrated several methods always exhibited each these three capacities. For example, chronic infection with C56 strain Toxoplasma gondii killed Corynebacterium parvum inhibited multiplication T. gondii9–11, DNA synthesis target cells12,13, mitogen- antigen-specific lymphocyte transformation14. Whether different populations which been defined one criterion possess other capacities as well, however, not established. We report here characterised do necessarily characteristics differences capacity depend method used activate macrophages.