Verifying Radiation Treatment in Proton Therapy via PET Imaging of the Induced Positron-Emitters

摘要: Abstract Positron Emission Topography (PET) is a promising technique to verify the dose distribution from proton therapy, precise treatment modality increasingly used in radiation oncology because its pattern conforms more closely configuration of tumor than does that X-ray radiation, thereby sparing normal healthy tissue. Proton therapy produces positron-emitting isotopes along beam’s path, allowing PET image therapeutic energy, viz., form quality assurance treatment. This ability especially important when treating heterogeneous organs, such as lungs or head-and-neck, where calculating expected for complex. Here, we present findings our Monte Carlo simulations yield positron emitters produced by beams up 250 MeV, followed statistically realistic simulation images clinical scanner. Our emphases lay predicting accurately emitters, and determining signal near Bragg peak critical success imaging verifying location dosimetry. We also demonstrate results depend strongly on accuracy available nuclear reaction cross section data. Accordingly, quantify differences calculated positron-emitter yields four different sets data, comparing them simulated distributions production absorbed energies.