Cerium dioxide (CeO2) nanoparticles decrease arsenite (As(III)) cytotoxicity to 16HBE14o- human bronchial epithelial cells.

摘要: Abstract The production and application of engineered nanoparticles (NPs) are increasing in demand with the rapid development nanotechnology. However, there concerns that some these novel materials could lead to emerging environmental health problems. Some NPs able facilitate transport contaminants into cells/organisms via a “Trojan Horse” effect which enhances toxicity adsorbed materials. In this work, we evaluated arsenite (As(III)) onto cerium dioxide (CeO2) human bronchial epithelial cells (16HBE14o-) using xCELLigence real time cell analyzing system (RTCA). Application 0.5 mg/L As(III) resulted 81.3% reduction index (CI, an RTCA measure toxicity) over 48 h when compared control exposed medium lacking As(III). were presence CeO2 (250 mg/L), CI was only reduced by 12.9% control. had high capacity for adsorption (20.2 mg/g CeO2) bioassay medium, effectively reducing dissolved aqueous solution resulting toxicity. Transmission electron microscopy used study 16HBE14o- cells. NP uptake engulfment observed internalized accumulated vesicles. results demonstrate decisive factor controlling cells, available through adsorption. These data emphasize evaluation mixtures assaying