EGFR-dependent mechanisms in glioblastoma: towards a better therapeutic strategy

摘要: Glioblastoma is a particularly resilient cancer, and while therapies may be able to reach the brain by crossing blood–brain barrier, they then have deal with highly invasive tumor that very resistant DNA damage. It seems clear in order kill aggressive glioma cells more efficiently fewer side effects on normal tissue, there must shift from classical cytotoxic chemotherapy targeted therapies. Since epidermal growth factor receptor (EGFR) altered almost 50 % of glioblastomas, it currently represents one most promising therapeutic targets. In fact, has been associated several distinct steps tumorigenesis, initiation survival, also regulation cell migration angiogenesis. However, inhibitors EGFR kinase produced poor results this type cancer clinical trials, no explanation for resistance observed. Here we will review what know about expression function particular gliomas. We evaluate which are possible molecular cellular escape mechanisms. As result, hope help improve design future EGFR-targeted glioblastomas.