Antihistamines in urticaria and angioedema.

摘要: H1-antihistamines are the cornerstone of symptomatic treatment in acute and chronic urticaria, which they not only relieve itching, but also reduce number, size, duration urticarial lesions. Relief whealing, flaring, erythema may be incomplete as vascular effects histamine mediated to its action at H2-receptors well H1-receptors, other vasoactive substances involved. In randomized, prospective, placebo-controlled, double-blind studies, new low-sedating have been found effective safe urticaria. Sedating antihistamines, although effective, place patients risk for adverse effects, including decreased psychomotor performance. The response some types example, vasculitis, is unsatisfactory. An H2-antihistamine administered concurrently with an H1-antihistamine modestly enhance relief itching wheal formation urticaria refractory alone. available evidence does justify routine addition treatment.