Probing the Interactions of Intrinsically Disordered Proteins Using Nanoparticle Tags
作者： Stive Pregent , Amir Lichtenstein , Ram Avinery , Adi Laser-Azogui , Fernando Patolsky
DOI: 10.1021/ACS.NANOLETT.5B00073
关键词:
摘要: The structural plasticity of intrinsically disordered proteins serves as a rich area for scientific inquiry. Such lack fix three-dimensional structure but can interact with multiple partners through numerous weak bonds. Nevertheless, this intrinsic possesses challenging hurdle in their characterization. We underpin the intermolecular interactions between neurofilaments various hydrated conditions, using grafted gold nanoparticle (NP) tags. Beyond its biological significance, approach be applied to modify surface interaction NPs creation future tunable “smart” hybrid biomaterials.
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