Endothelin as a Putative Mediator in Asthma and Other Respiratory Diseases

摘要: In the decade since discovery of endothelins (ETs), there has been a rapid expansion knowledge concerning their molecular biology, biological effects, and expression in health disease. Significant attention focused on lung, role for ETs pathophysiology number respiratory diseases proposed. Research into is now moving new phase as result availability potent selective ET receptor antagonists synthesis inhibitors. Over next few years, clinical studies using these agents should provide more definitive answers to many questions that have raised. It would seem timely, therefore, review our present understanding regarding properties pulmonary system current evidence implicate peptides mediators asthma other disorders.