Increased cerebrospinal fluid cAMP levels in Alzheimer's disease.
作者： Marcos Martı́nez , Estrella Fernández , Ana Frank , Carmen Guaza , Mónica de la Fuente
DOI: 10.1016/S0006-8993(99)01981-2
关键词:
摘要: Since increasing evidence suggests that upregulation of the cAMP-second messenger system may be implicated in Alzheimer's disease neurodegeneration, we have compared cAMP and cGMP levels cerebrospinal fluid (CSF) from patients with dementia Alzheimer type (DAT, n=10) those nondemented age-matched controls (n=10). Our results show levels, but not cGMP, are significantly (p<0.01) elevated CSF DAT to controls. Moreover, a linear regression analysis demonstrated significant correlation (r=0.62; p<0.01) between tau protein when were studied together. These suggest cAMP-signaling pathway is physiopathology.
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