Splanchnic ischaemia/reperfusion and multiple organ failure.

摘要: failure was blamed for over 50 % of later fatalities [127]. Basic scientific investigations supported the addition crystalloid solutions to blood transfusions. More vigorous fluid resuscitation during Vietnam War led a 20- 30-fold reduction in incidence renal compared with Korean experience. However, new problem came forefront Vietnam: “shock lung”—the acute respiratory distress syndrome (ARDS) [8]. Of note, accounts conflict, there virtually no mention pulmonary problems. Advances care, and particularly mechanical ventilation, allowed more patients survive ARDS. Today, while our ability sustain on ventilation has improved, number dying ARDS remains high; this is because actual cause death shifted MOF. The identification MOF as distinct entity dates back 1973, when Tilney, Bailey Morgan [128] described progressive organ systems following repair ruptured abdominal aortic aneurysms. Baue [15] first suggested sequential pattern syndrome. In 1977, Eiseman, Beart Norton [40] at institution its clinical presentation coined term “multiple failure”. Since that time, intensive research efforts have targeted