Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in alzheimer's brains

摘要: Summary Point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 (ND2) were detected 10 19 Alzheimer's brains but not 11 normal brains. The same also 6 patients with amyotrophic lateral sclerosis (ALS). However, neurofibrillary tangles and neuritic plaques characteristic disease found histologically the brain one ALS patient who was positive mutation. finding suggests that a point mutation ND2 is potential risk factor for disease.