Recent Development of Benzimidazole‐Containing Antibacterial Agents
作者： Di Song , Shutao Ma
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摘要: Clinically significant antibiotic resistance is one of the greatest challenges twenty-first century. However, new antibacterial agents are currently being developed at a much slower pace than our growing need for such drugs. Given their diverse biological activities and clinical applications, many bioactive heterocyclic compounds containing benzimidazole nucleus have been focus interest researchers. The structural isostere naturally occurring nucleotides. This advantage allows benzimidazoles to readily interact with various biopolymers found in living systems. In view this situation, attention has given exploration benzimidazole-based agents, leading discovery chemical entities intriguing profiles. minireview we summarize novel derivatives active against bacterial strains. particular, outline relationship between structures variously modified activity.
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