Polyhydroxyamino‐Piperidine‐Type Iminosugars and Pipecolic Acid Analogues from a D‐Mannose‐Derived Aldehyde
作者： Camilla Matassini , Stefania Mirabella , Xhenti Ferhati , Cristina Faggi , Inmaculada Robina
关键词:
摘要: A general strategy for the synthesis of diversely substituted 3,4,5-trihydroxypiperidines (including two natural products), 5-amino-3,4-dihydroxypiperidines, 3,4,5-trihydroxypipecolic acids, and 2-(aminomethyl)-3,4,5-trihydroxypiperidines is reported. The procedure used a double reductive amination or Strecker reaction, starting from differently protected aldehydes readily synthesized on gram scale D-mannose. biological activities target compounds were evaluated, some them showed moderate inhibition α-L-fucosidase β-glucosidase.
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