Di-vanilloyl and tri-vanilloyl derivatives for use in anti-cancer therapy

作者: Delphine Lamoral-Theys , François Dufrasne , Robert Kiss , Jacques Dubois , Laurent Pottier

DOI:

关键词:

摘要: The invention relates to the medical field, more precisely in field of anti-cancer treatment and Alzheimer's disease, Parkinson's disease or Pick's for ameliorating symptoms Down syndrome, providing newly synthesised multi-vanilloyl derivative compounds their use said disorders.

参考文章(18)
Tak-Hang Chan, Q. Ping Dou, David M. Smith, Polyphenol proteasome inhibitors, synthesis, and methods of use ,(2007)
María Font, Elena Ardaiz, Lucia Cordeu, Elena Cubedo, Jesús García-Foncillas, Carmen Sanmartin, Juan-Antonio Palop, Structural characteristics of novel symmetrical diaryl derivatives with nitrogenated functions. Requirements for cytotoxic activity Bioorganic & Medicinal Chemistry. ,vol. 14, pp. 1942- 1948 ,(2006) , 10.1016/J.BMC.2005.10.041
Delphine Lamoral-Theys, Touria Lamkami, Benjamin Le Calve, Pierre Van Antwerpen, François Dufrasne, Véronique Megalizzi, Robert Kiss, Michel Gelbcke, Jean Neve, Laurent Pottier, Jacques Dubois, New Polyol Vanilloyl Esters with Anti-tumor Effects ,(2009)
Carmen Sanmartin, Elena Ardaiz, Lucia Cordeu, Elena Cubedo, Jesus Garcia-Foncillas, Maria Font, Juan Palop, Symmetrical Derivatives with Nitrogenated Functions as Cytotoxic Agents and Apoptosis Inducers Letters in Drug Design & Discovery. ,vol. 2, pp. 341- 354 ,(2005) , 10.2174/1570180054405794
L. A. Grigoryan, M. R. Kaldrikyan, F. G. Arsenyan, G. M. Stepanyan, B. T. Garibdzhanyan, Arylsulfonic acid derivatives. Synthesis and antitumor activity of di- and tetra(benzylsulfonyl)diamines Pharmaceutical Chemistry Journal. ,vol. 34, pp. 186- 188 ,(2000) , 10.1007/BF02524594
Irwin A. Pearl, Donald L. Beyer, Reactions of vanillin and its derived compounds; some new esters of vanillic acid and related acids. Journal of the American Chemical Society. ,vol. 71, pp. 1066- 1068 ,(1949) , 10.1021/JA01171A086
Jenny BAIN, Hilary McLAUCHLAN, Matthew ELLIOTT, Philip COHEN, The specificities of protein kinase inhibitors: an update. Biochemical Journal. ,vol. 371, pp. 199- 204 ,(2003) , 10.1042/BJ20021535
Badioré Ouattara, Luc Angenot, Pierre Guissou, Pierre Fondu, Jacques Dubois, Michel Frédérich, Olivia Jansen, Jean-Claude Van Heugen, Jean-Noël Wauters, Monique Tits, LC/MS/NMR analysis of isomeric divanilloylquinic acids from the root bark of Fagara zanthoxyloides Lam. Phytochemistry. ,vol. 65, pp. 1145- 1151 ,(2004) , 10.1016/J.PHYTOCHEM.2004.02.025