Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure model
作者： Paven K. Aujla , Michael R. Fetell , Frances E. Jensen
DOI: 10.1111/J.1528-1167.2008.01947.X
关键词:
摘要: Purpose To test the efficacy of novel candidate anticonvulsant talampanel (GYKI 53773) in a rodent model hypoxic neonatal seizures. Talampanel is noncompetitive antagonist alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid subtype glutamate receptor (AMPAR). We have previously shown that AMPARs play critical role generation acute seizures and later-life seizure susceptibility this
sci-hub.se 参考文章(63)
Steven P. Miller, Vijay Ramaswamy, David Michelson, A. James Barkovich, Barbara Holshouser, Nathaniel Wycliffe, David V. Glidden, Douglas Deming, J. Colin Partridge, Yvonne W. Wu, Stephen Ashwal, Donna M. Ferriero, Patterns of brain injury in term neonatal encephalopathy The Journal of Pediatrics. ,vol. 146, pp. 453- 460 ,(2005) , 10.1016/J.JPEDS.2004.12.026
Raman Sankar, Michael J. Painter, Neonatal seizures: after all these years we still love what doesn't work. Neurology. ,vol. 64, pp. 776- 777 ,(2005) , 10.1212/01.WNL.0000157320.78071.6D
Russell M Sanchez, Weimin Dai, Rachel E Levada, Jocelyn J Lippman, Frances E Jensen, AMPA/kainate receptor-mediated downregulation of GABAergic synaptic transmission by calcineurin after seizures in the developing rat brain. The Journal of Neuroscience. ,vol. 25, pp. 3442- 3451 ,(2005) , 10.1523/JNEUROSCI.0204-05.2005
P. Bittigau, M. Sifringer, K. Genz, E. Reith, D. Pospischil, S. Govindarajalu, M. Dzietko, S. Pesditschek, I. Mai, K. Dikranian, J. W. Olney, C. Ikonomidou, Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 15089- 15094 ,(2002) , 10.1073/PNAS.222550499
Carl E Stafstrom, Pushpa Tandon, Ariyuki Hori, Zhao Liu, Mohamad A Mikati, Gregory L Holmes, Acute effects of MK801 on kainic acid-induced seizures in neonatal rats Epilepsy Research. ,vol. 26, pp. 335- 344 ,(1997) , 10.1016/S0920-1211(96)00904-7
Yvonne M Langan, Richard Lucas, Haley Jewell, Nathalie Toublanc, Hans Schaefer, Jasemire WAS Sander, Philip N Patsalos, None, Talampanel, a new antiepileptic drug: single- and multiple-dose pharmacokinetics and initial 1-week experience in patients with chronic intractable epilepsy. Epilepsia. ,vol. 44, pp. 46- 53 ,(2003) , 10.1046/J.1528-1157.2003.128902.X
Roustem Khazipov, Ilgam Khalilov, Roman Tyzio, Elena Morozova, Yezekiel Ben-Ari, Gregory L. Holmes, Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus. European Journal of Neuroscience. ,vol. 19, pp. 590- 600 ,(2004) , 10.1111/J.0953-816X.2003.03152.X
Elisabeth W.P.M Daenen, Gerrit Wolterink, Mirjam A.F.M Gerrits, Jan M Van Ree, The effects of neonatal lesions in the amygdala or ventral hippocampus on social behaviour later in life. Behavioural Brain Research. ,vol. 136, pp. 571- 582 ,(2002) , 10.1016/S0166-4328(02)00223-1
A. S. Chappell, J. W. Sander, M. J. Brodie, D. Chadwick, A. Lledo, D. Zhang, J. Bjerke, G. M. Kiesler, S. Arroyo, A crossover, add-on trial of talampanel in patients with refractory partial seizures Neurology. ,vol. 58, pp. 1680- 1682 ,(2002) , 10.1212/WNL.58.11.1680
Rita Jakus, Marton Graf, Romeo D Ando, Brigitta Balogh, Istvan Gacsalyi, Gyorgy Levay, Sandor Kantor, Gyorgy Bagdy, Effect of two noncompetitive AMPA receptor antagonists GYKI 52466 and GYKI 53405 on vigilance, behavior and spike–wave discharges in a genetic rat model of absence epilepsy Brain Research. ,vol. 1008, pp. 236- 244 ,(2004) , 10.1016/J.BRAINRES.2004.01.087