Effects of substance P on renin release and renal function in anesthetized dogs.
作者： Hans-G. Gullner , William B. Campbell , William A. Pettinger
DOI: 10.1016/0024-3205(79)90225-X
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摘要: Abstract Substance P (SP), a naturally occuring undecapeptide with hypotensive, vasodilatory and smooth muscle stimulating properties, was infused intravenously or intrarenally into anesthetized dogs. Infusions of SP suppressed renin secretion rate (RSR) from 204±45 to 52±18 ng/min (p 0.1). Both intravenous intrarenal administration the peptide significantly lowered arterial blood pressure at highest two doses. Intrarenal infusion resulted in significant dose-related increase urine volume, sodium potassium excretion, renal flow. In contrast, infusions did not alter these parameters. Thus suppresses release presence absence diuresis, natriuresis, vasodilation.
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