The Pharmacokinetics and Safety of Deuterated-Tetrabenazine (P07.210)

摘要: OBJECTIVE: To compare the pharmacokinetics (PK) of deuterated-tetrabenazine (SD-809) and tetrabenazine (TBZ) and their respective metabolites. BACKGROUND: TBZ is approved for the treatment of chorea associated with HD. TBZ is rapidly and extensively converted to active metabolites α-dihydrotetrabenazine (HTBZ) and β-HTBZ, which are in turn metabolized by CYP2D6-mediated O-demethylation. Limitations of TBZ include frequent dosing, short half-life (of metabolites) and high peak concentrations which are often …