Resolving the enigma of embryonic diapause, a forty-year scientific journey

摘要: Embryonic diapause is an evolutionary strategy by which a reversible arrest in embryo development occurs. In its two forms, facultative and obligate, it assures that offspring are born when optimal maternal environmental conditions present to ensure maximal survival. We have explored obligate delayed implantation the mink over four decades, first evaluation of regulation, then determination pituitary factors maintain provoke followed ovarian contribution process. As uterine environment proximal regulator diapause, we employed global gene analysis discover differentially expressed pathways during reactivation. These trials revealed synthesis polyamines was increased uterus with reactivation vivo. Subsequent experiments demonstrated polyamine, putrescine, capable inducing escape from providing strong evidence paucity induces developmental coupled renewed and/embryonic these polycations.