Protein quality control in the endoplasmic reticulum
作者： Paul-Albert Koenig , Hidde L. Ploegh
DOI: 10.12703/P6-49
关键词:
摘要: The topological barriers defined by biological membranes are not impermeable: from small solutes to intact proteins, specialized transport and translocation mechanisms adjust the cell's needs. Here, we review removal of unwanted proteins endoplasmic reticulum (ER) emphasize need extend observations tissue culture models simple eukaryotes studies in whole animals. variation protein production composition that characterizes different cell types tissues requires tailor-made solutions exert proper control over both synthesis breakdown. ER is an organelle essential achieve maintain such homeostasis.
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