Fusion-mediated chromosomal instability promotes aneuploidy patterns that resemble human tumors

摘要: Oncogenesis is considered to result from chromosomal instability, in addition oncogene and tumor-suppressor alterations. Intermediate aneuploidy genome doubling a frequent event tumor development but the mechanisms driving tetraploidization its impact remain unexplored. Cell fusion, one of pathways tetraploidy, physiological process involved mesenchymal cell differentiation. Besides simple doubling, fusion results merging two different genomes that can be destabilized upon proliferation. By testing whether oncogenesis, we provide evidence it induces genomic instability mediates initiation. After latency period, emerges with cells most suited for development. Furthermore, hybrid were stabilized after this selection very close those human pleomorphic tumors. Thus restructuring triggered by may account oncogenesis.