A fluorescent probe for the discrimination between Cys and GSH
作者： Lun Song , Qian Sun , Nan Wang , Zhaoyang Chen , Weibing Zhang
DOI: 10.1039/C5AY02354H
关键词:
摘要: Fluorescent probe RTP was rationally designed and synthesized to differentially detect cysteine (Cys) glutathione (GSH) in different channels. constructed by incorporating a nitrothiophenyl receptor rhodamine fluorophore. The replacement of the mercapto group biothiols forms weakly fluorescent thioether. amino Cys/Hcy further attacks thioether through aromatic nucleophilic substitution via five/six-membered ring form highly red-emitting amino-substituted rhodamine. Moreover, has been successfully used for fluorescence imaging Cys living Hela cells.
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sci-hub.se 参考文章(54)
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