Circulating endothelin-1 levels in type 2 diabetic patients with ischaemic heart disease
作者： M. Donatelli , E. Hoffmann , I. Colletti , G. Andolina , V. Russo
DOI: 10.1007/BF02048552
关键词:
摘要: To investigate whether circulating endothelin-1 (Et-1) may be related to the increased incidence and severity of ischaemic heart disease in type 2 diabetes mellitus, we compared concentrations diabetic patients non-diabetic with coronary artery (CAD) angiographically documented. Plasma levels Et-1 were determined 34 CAD (16 stable angina, 6 unstable 12 previous myocardial infarction) 19 (4 5 10 infarction). Fifteen without 9 healthy volunteers served as control subjects. In patients, mean 3.19±1.61 pmol/l those 3.58±1.92 4.24±2.53 infarction. These values not significantly different one another, nor from obtained controls (3.64±2.13 pmol/l). 3.92±0.73 4.35±1.67 4.33±1.66 but higher than (2.07±0.67 pmol/l;P<0.001). No significant differences found between stable, angina contrast, a statistically difference was subjects (P<0.05). conclusion, similar raised infarction do support hypothesis that are responsible for mellitus. However, absence strongly suggest generalised endothelial dysfunction, documented our study by Et-1, most probably precedes subsequent cardiovascular diseases.
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sci-hub.se 参考文章(15)
J. L. Balligand, T. Godfraind, Effect of nisoldipine on contractions evoked by endothelin-1 in human isolated distal and proximal coronary arteries and veins. Journal of Cardiovascular Pharmacology. ,vol. 24, pp. 618- 625 ,(1994) , 10.1097/00005344-199410000-00013
Issei Komuro, Hiroki Kurihara, Takao Sugiyama, Fumimaro Takaku, Yoshio Yazaki, Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells. FEBS Letters. ,vol. 238, pp. 249- 252 ,(1988) , 10.1016/0014-5793(88)80489-7
K. Ando, Y. Hirata, M. Shichiri, T. Emori, F. Marumo, Presence of immunoreactive endothelin in human plasma. FEBS Letters. ,vol. 245, pp. 164- 166 ,(1989) , 10.1016/0014-5793(89)80213-3
Zhihong Yang, Vincent Richard, Ludwig von Segesser, Erwin Bauer, Peter Stutz, Marko Turina, Thomas F. Lüscher, Endothelin-1 potentiates contractions to norepinephrine and serotonin in human mammary and coronary arteries Journal of the American College of Cardiology. ,vol. 15, ,(1990) , 10.1016/0735-1097(90)91769-Q
William B. Kannel, Ralph B. D'Agostino, Peter W.F. Wilson, Albert J. Belanger, David R. Gagnon, Diabetes, fibrinogen, and risk of cardiovascular disease: The Framingham experience American Heart Journal. ,vol. 120, pp. 672- 676 ,(1990) , 10.1016/0002-8703(90)90026-T
Z H Yang, V Richard, L von Segesser, E Bauer, P Stulz, M Turina, T F Lüscher, Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries. A new mechanism of vasospasm? Circulation. ,vol. 82, pp. 188- 195 ,(1990) , 10.1161/01.CIR.82.1.188
M I Uusitupa, L K Niskanen, O Siitonen, E Voutilainen, K Pyörälä, 5-year incidence of atherosclerotic vascular disease in relation to general risk factors, insulin level, and abnormalities in lipoprotein composition in non-insulin-dependent diabetic and nondiabetic subjects. Circulation. ,vol. 82, pp. 27- 36 ,(1990) , 10.1161/01.CIR.82.1.27
Y. Iwashima, T. Sato, K. Watanabe, E. Ooshima, S. Hiraishi, H. Ishii, M. Kazama, I. Makino, Elevation of plasma thrombomodulin level in diabetic patients with early diabetic nephropathy. Diabetes. ,vol. 39, pp. 983- 988 ,(1990) , 10.2337/DIAB.39.8.983
CD.A. Stehouwer, G.C. Zeldenrust, GJ.H. den Ottolander, W.H.L. Hackeng, A.J.M. Donker, J.J.P. Nauta, Urinary albumin excretion, cardiovascular disease, and endothelial dysfunction in non-insulin-dependent diabetes mellitus The Lancet. ,vol. 340, pp. 319- 323 ,(1992) , 10.1016/0140-6736(92)91401-S
Yukio Hirata, Yasuyuki Takagi, Yuka Fukuda, Fumiaki Maruno, Endothelin is a potent mitogen for rat vascular smooth muscle cells Atherosclerosis. ,vol. 78, pp. 225- 228 ,(1989) , 10.1016/0021-9150(89)90227-X