Characteristics of victims of non-ischemic sudden cardiac death

摘要: A non-ischemic etiology of sudden cardiac death (SCD), mostly due to various cardiomyopathies (CMP), accounts for about 20% all SCDs. Most the major studies risk factors SCD have focused on coronary artery disease (CAD). The aim present study was clarify characteristics in Northern Finland. In this study, consecutive victims (n=2661) were prospectively collected, and among whom post-mortem examinations performed between 1998 2007. Information obtained from a combination available medical records, postmortem examination reports, medication used at time SCD, standardized questionnaire filled out by closest family members SCD. We also screened candidate genes Finnish which fatal arrhythmias first manifestation disease. collagen content myocardium histological samples idiopathic myocardial fibrosis (IMF) evaluated. CAD most common cause (2082 victims, 78.2%). prevalence nonischemic SCDs 21.8% After sub-grouping into categories, CMP related obesity (23.7%), followed alcoholic (19.0%), hypertensive (15.5%) IMF (13.6%). association with is notably frequent <40 years old (28.3%). history significantly higher ischemic (34.2%) than (13.4%, P<0.001) or controls (17.6%, P<0.001). Lamin A/C gene mutation R541C found family, predominant pathologic-anatomic finding. Myocardial type I synthesis increased IMF. conclusion, Finland differ those reported previously. Higher prevalences CMP-associated obesity, observed as clinical and/or pathologic bases not suggesting larger role sporadic occurrence inherited traits Replacement myocytes can be responsible subjects lamin mutation. synthesis.