Vitamin K-dependent carboxylation: inhibition by a peptide containing 4-methylene glutamic acid.
作者： Eryka Guibé , Paulette Decottignies-Le Maréchal , Pierre Le Maréchal , Robert Azerad
DOI: 10.1016/0014-5793(84)81296-X
关键词:
摘要: Abstract The peptide Boc-4-methylene Glu-Glu-Val has been synthesized and shown to be a strong inhibitor of the vitamin K-dependent carboxylation catalyzed by detergent solubilized rat liver microsome preparation. inhibition is apparently competitive with respect substrate non-competitive HCO3− Vitamin KCarboxylation4-Methylene glutamic acidγ-Carboxyglutamic acid
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