Recombinant hirudin in patients with chronic, stable coronary artery disease. Safety, half-life, and effect on coagulation parameters.
作者： P Zoldhelyi , M W Webster , V Fuster , D E Grill , D Gaspar
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摘要: BACKGROUNDBecause the specific antithrombin hirudin prevents platelet-rich arterial thrombus and accelerates thrombolysis in a variety of animal models, it has promise as antithrombotic therapy. We therefore studied half-life, effect on anticoagulant parameters, safety patients with coronary artery disease.METHODS AND RESULTSThirty-eight men 1 woman (age [mean +/- SD], 60.4 6.9 years) angiographic disease were allocated single-blind ascending dosage study to 6-hour i.v. infusion recombinant (CGP 39,393) or matching placebo. The median terminal half-life for hirudin, measured by ELISA, was 2.7, 2.3, 2.9, 3.1, 2.0 hours 0.02, 0.05, 0.1, 0.2, 0.3 mg.kg-1 x h-1 groups, respectively. Activated partial thromboplastin times (aPTT) at 3, 4, 6 averaged into plateau value. aPTT plateau-to-baseline ratios 1.5 2.3 2.7 2.9 respectively, infused 0.0...
sci-hub.se 参考文章(37)
Charles W. Pumphrey, James H. Chesebro, Mrinal K. Dewanjee, Heinz W. Wahner, Larry H. Hollier, Peter C. Pairolero, Valentin Fuster, In vivo quantitation of platelet deposition on human peripheral arterial bypass grafts using indium-111-labeled platelets: Effect of dipyridamole and aspirin American Journal of Cardiology. ,vol. 51, pp. 796- 801 ,(1983) , 10.1016/S0002-9149(83)80136-2
SE Lind, The bleeding time does not predict surgical bleeding (see comments) Blood. ,vol. 77, pp. 2547- 2552 ,(1991) , 10.1182/BLOOD.V77.12.2547.2547
MASASHI UNO, HAJIME TSUJI, MASAHIKO WATANABE, OSAMU TAKADA, KYOICHIRO KOBAYASHI, HIROAKI TAKABUCHI, KAORI SHIRAI, SHOHEI SAWADA, TAKEO TOYODA, KATSUMI YAMAMOTO, KAZUHARU KATOH, MASAO NAKAGAWA, Application of thrombin-antithrombin III complex for detecting a latent hypercoagulable state in patients with coronary artery disease. Japanese Circulation Journal-english Edition. ,vol. 53, pp. 1185- 1191 ,(1989) , 10.1253/JCJ.53.1185
Peter C. Block, Richard K. Myler, Simon Stertzer, John T. Fallon, Morphology after Transluminal Angioplasty in Human Beings New England Journal of Medicine. ,vol. 305, pp. 382- 385 ,(1981) , 10.1056/NEJM198108133050706
Jules Y.T. Lam, James H. Chesebro, Peter M. Steele, Mrinal K. Dewanjee, Lina Badimon, Valentin Fuster, Deep arterial injury during experimental angioplasty: relation to a positive indium-111-labeled platelet scintigram, quantitative platelet deposition and mural thrombosis. Journal of the American College of Cardiology. ,vol. 8, pp. 1380- 1386 ,(1986) , 10.1016/S0735-1097(86)80311-4
J. N. Wilcox, K. M. Smith, S. M. Schwartz, D. Gordon, Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 2839- 2843 ,(1989) , 10.1073/PNAS.86.8.2839
J. Bichler, R. Gemmerli, H. Fritz, Studies for revealing a possible sensitization to hirudin after repeated intravenous injections in baboons Thrombosis Research. ,vol. 61, pp. 39- 51 ,(1991) , 10.1016/0049-3848(91)90167-U
Christopher P. Cannon, John M. Maraganore, Joseph Loscalzo, Arthur McAllister, Karen Eddings, Dorinda George, Andrew P. Selwyn, Burt Adelman, Irving Fox, Eugene Braunwald, Peter Ganz, Anticoagulant effects of hirulog, ∗∗Hirulog™ brand direct thrombin inhibitor. a novel thrombin inhibitor, in patients with coronary artery disease The American Journal of Cardiology. ,vol. 71, pp. 778- 782 ,(1993) , 10.1016/0002-9149(93)90823-U
K A Bauer, L M Weiss, D Sparrow, P S Vokonas, R D Rosenberg, Aging-associated changes in indices of thrombin generation and protein C activation in humans. Normative Aging Study. Journal of Clinical Investigation. ,vol. 80, pp. 1527- 1534 ,(1987) , 10.1172/JCI113238
Mary Ann Lukas Laskey, Ezra Deutsch, John W. Hirshfeld, William G. Kussmaul, Elliot Barnathan, Warren K. Laskey, Influence of heparin therapy on percutaneous transluminal coronary angioplasty outcome in patients with coronary arterial thrombus The American Journal of Cardiology. ,vol. 65, pp. 179- 182 ,(1990) , 10.1016/0002-9149(90)90081-B